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[DOI] [PMC free article] [PubMed] [Google Scholar] Fontaine J.X., Terc-Laforgue T., Armengaud P., Clment G., Renou J.P., Pelletier S., Catterou M., Azzopardi M., Gibon Y., Lea P.J., et al

developed a complex (DDC/Cu-Fe) formed by chelating diethyldithiocarbamate (DDC) with copper and ferrous ions, which activates T-cell immune responses in the TME, inhibits the ability of TAMs to alleviate immunosuppression, and can be encapsulated in nanomaterials to target the BBB and overexpress nutrient transporters in the GBM for anticancer immunity (163)

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With improvement space the doses further apart