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The reninangiotensin aldosterone system (RAAS) through angiotensin II (AngII) can stimulate NAD(P)H oxidase and is involved in the generation of ROS

In chemotherapy-sensitive patients, Keap1 (Kelch-like ECH-associated protein 1) binds to NRF2 and mediates NRF2 ubiquitination via the Cul3-E3 ligase complex, promoting its degradation and maintaining NRF2 at low levels [32]

I want to talk about this new study that's from the American Heart Association

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336,337 Failure of glutamate homoeostasis in epilepsy reflects significant down-regulation of astrocytic glutamate transporters and glutamine synthetase, the two principal components of the glutamate (GABA)-glutamine shuttle
