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doi: 10.1016/j.bbagen.2012.07.006

We did not observe metabolite-induced aggregate formation in subthreshold PolyQ 19 or GFP only strains (data not shown), indicating that the metabolite alters the ability of threshold-state animals to handle polyQ misfolding

Iodine deficiency consequences People at the highest risk for iodine deficiency include (2): Pregnant women Those who live in countries with iodine-deficient soil (including South Asia, Southeast Asia, New Zealand, and European countries ) Those who dont use iodized salt (or take iodine supplements- well talk about the issues with iodized salt soon) Those who are vegans or vegetarians Consequences of an iodine deficiency include (1): Goiter formation Hypothyroidism Autoimmune thyroid diseases (Graves and Hashimotos) Thyroid cancer The American Thyroid Association estimates that more than 12 percent of the United States population will develop a thyroid condition at some point in their lifetime