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This finding may suggest an important role of detoxifying transformations in UA metabolism, the consequences of which for the anticancer and/or toxic activities of the compounds are not yet well understood

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In the UK, deficiency is particularly prevalent among older adults, vegans, and those with gastrointestinal disorders

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines (Higgins and Green, 2008)