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M0 macrophages exhibited the highest permissiveness to cell-to-cell HIV-R5 infection (36.8 18.6%), followed by M2 (27.7 18.4%) and M1 (5.4 3.8%)

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It acts as a master regulator, boosting genes involved in cellular repair, reducing inflammation, and promoting tissue regeneration, while down-regulating genes that trigger unwanted inflammatory responses