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Informed consent was obtained from all parents/participants, and this study was approved by the Ethical Committee of the Medical Research, University of Indonesia (No 1050/UN2.F1/Ethic/2015)

doi: 10.1021/acsfoodscitech.1c00046 40

In vivo studies confirmed trans-epithelial and axonal transport of nanoparticles, with intranasal administration achieving substantially elevated MEL brain concentrations compared to intravenous or oral delivery

The cortex tissue in all animals was divided into 2 halves: the left half was used to determine monoamine levels, while the right half was used to measure oxidative stress

Over the following 2 weeks she developed a raised anion gap acidosis and positive urinary anion gap