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The paper explores the science at the intersection of metabolic hormones and precision nutrition and multi-target therapies, like tirzepatide and retatrutide.

Acknowledgements This work was supported by the Novo Nordisk Foundation, CEMBID (Center for Multifunctional Biomolecular Drug Design), Grant Number: NNF17OC0028070, and the Spanish Ministry of Economy and Competitiveness (SAF2017-89437-P)

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