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Furthermore, engineered monoclonal antibodies that have increased affinity for activating FcRs are superior to wild-type antibodies at treating and preventing clinical signs of SARS-CoV-2 infection in rodent models 172

If a step provokes strong GI symptoms, the documented approach is to hold at the current dose (or step back down) rather than push forward on the calendar

Finally, the binding site of lumacaftor, a clinically used corrector that stabilizes unfolded CFTR, binds in the outer perimeter of NBD1 near the R-domain binding site 37

It triggers the body to form fresh capillary networks, rapidly increasing blood flow to damaged or oxygen-starved tissues