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10.1016/j.drudis.2021.05.011 34 GaoY.Van HarenM

Rare risks include copper toxicity, particularly in individuals with underlying conditions such as Wilsons disease (a genetic disorder causing copper accumulation), and theoretical concerns regarding angiogenesis promotion in the context of active cancers

Additional investigations have explored relationships between GHK-Cu and copper-dependent regulatory proteins, redox-associated signaling pathways, and metalloprotein activity, contributing to a broader understanding of metallopeptide signaling systems

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