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Vertebrate animal models Toxin-induced models Quinolinic acid (QA) model Quinolinic acid selectively targets medium spiny neurons (MSNs) in the striatum, mimicking HDs excitotoxic mechanisms (Ca 2 dysregulation, ATP depletion) and manifesting an early-stage hyperkinetic symptoms (Bordelon et al

[DOI] [PubMed] [Google Scholar] Spiteller P

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However, their effectiveness is highly dependent to patient breathing pattern and requires patient coordination between actuation of the device and the breath pattern

[ 345 ] BACH1 deficiency alleviates dextran sodium sulfate (DSS)induced colitis by upregulating HO1 expression