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Tang ZLY, Shi Z et al (2015) BGB-290, a novel PARP inhibitor with unique brain penetration ability, demonstrated strong synergism with temozolomide in subcutaneous and intracranial xenograft models

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

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Ablation of GCLC prevents optimal TCR-induced MYC expression and NFAT activation, through unknown mechanisms, dampening aerobic glycolysis and glutaminolysis (63)

All together, under high glutamine conditions, GS catalytic activity is product inhibited and GlnR/oligomeric state inhibited, and transcription of the glnRA operon is halted