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Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

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In fact, having lower B12 levels, even within the normal range, could increase the risk of cognitive impairment

PMC 6836378

What are the causes of vitamin B12 or folate deficiency