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Critically, IL-22 and IL-17 form a synergistic axis: IL-22 deficiency amplifies IL-17-driven inflammation, whereas IL-22 supplementation restores bacterial clearance and attenuates inflammation (167)This axis is vital during acute exacerbations, where bacterial infections (e.g., Streptococcus pneumoniae) cause delayed clearance due to IL-17/IL-22 defects, while viral infections (e.g., influenza) suppress their secretion by inhibiting IL-1/IL-23, raising secondary infection risks (168)

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2022 Aug 18;12(1):14047

It also works deep within the skin to restore its natural radiance, giving it a brighter, more youthful appearance

How long a B12 shot lasts depends on the form of B12 used in the injection, how severe your deficiency is, and how well your body absorbs the form thats being injected