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Janus kinase 2 This 56-year-old man presents with headaches, fatigue, splenomegaly, and marked erythrocytosis (hemoglobin 19.5 g/dL, hematocrit 59%) without a history of smoking

Overexpressing of FZD7 activates the oncogenic factor tumor protein 63 (TP63), leading to increased levels of glutathione metabolic pathways, including GPX4, which protects cells against chemotherapy-induced oxidative stress and ferroptosis

RAS oncogenes: weaving a tumorigenic web

10.1073/pnas.2422079122 141 NagaseY.IwasawaM.AkiyamaT.KadonoY.NakamuraM.OshimaY.et al (2009)

5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig
