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Accumulation of butyryl-carnitine has been associated with abnormal mitochondrial lipid -oxidation in T2D 54 , suggesting a link between TMAO and mitochondrial dysfunction consistent with the finding that TMAO binds to protein kinase R-like endoplasmic reticulum kinase and increases mitochondrial stress 55

Performance and energy metabolism in exercise In sport, the relationship between L-carnitine and fat utilisation and fatigue has been studied

L-Carnitine in Human Health and Disease

Rousseau AF, Dongier A, Colson C, Minguet P, Defraigne JO, Minguet G, Misset B, Boemer F

Furthermore, LC prevents the accumulation of long-chain acyl-CoA, thereby reducing the risk of life-threatening ventricular arrhythmias during ischemia (Cui et al