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However, the nature of different ions in salt formation, whether organic acids, inorganic, metallic, or non-metallic, significantly impacts the pharmacokinetic profile of the prodrug, influencing half-life, solubility, and, consequently, absorption, distribution, metabolism, and excretion

Inconspicuous symptoms at early stage, high recurrence, and facilitated chemotherapy resistance have collectively made it an urgent necessity to define novel therapeutic targets and explore new effective therapeutic strategies for epithelial ovarian cancer

If the metabolic pathways supplying GSH cannot maintain specific levels in the presence of highly expressed PCS, the consumption of GSH usually leads to changes in the GSH/GSSG ratio that exacerbate oxidative stress [62, 72]

Hawkes, H.J., T.C

Histological examination revealed improvements in both intestinal and hepatic tissues of supplemented groups