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Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
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This is most likely attributed to the inability of the constrained 13- and 14-membered macrocycles to adopt the proper transition states required for cleavage of the N-terminal peptide bond (Figure 8)
[Google Scholar] 114.Kurzer A.B., Dunn M.L., Pike O.A., Eggett D.L., Jefferies L.K
