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The underlying signaling cascade requires the binding of the cell surface receptor contactin1 to TnC FN(III) 5 and 6 domains (Weber et al, 1996)
Supplementation of antioxidants glutathione and -lipoic acid attenuates oxidative stress and Th2 response in allergic airway inflammation
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In fact, a cortactin mutation interrupting the binding to the Arp2/3 complex has been demonstrated to reduce the number of internalized bacteria into endothelial cells (Slanina et al., 2012)
Another issue is timing
