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Cancer 85 , 428430 (2001)

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Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype

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[DOI] [PubMed] [Google Scholar] 59.Vendemiale G., Altomare E., Trizio T., Le Grazie C., Di Padova C., Salerno M.T., Carrieri V., Albano O

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Studies have documented analgesic effects comparable to moderate doses of conventional pain medications in animal models, with prolonged duration of action extending beyond the peptide's short plasma half-life suggesting central nervous system mechanisms of action

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Further studies are required to determine the enzymes responsible for the formation of these oxidized metabolites and their roles in INH hepatotoxicity

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