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Slowly give the B12 solution

The link between epithelial permeability and pain likely reflects the abovementioned redundancy of the system involving the gut microbiota overstimulating the immune system through a leaky IEB, leading to the release of immune mediators, such as histamine, tryptase, serotonin, polyunsaturated fatty acids (12-hydroperoxyeicosatetraenoic acid, 15-hydroxyeicosatetraenoic acid, 5-hydroxyeicosatetraenoic acid, 5-oxoeicosatetraenoic acid, and leukotriene B4) (235, 236) known to evoke sensory afferent over-stimulation and pain (230)

however, there are limited human studies done to study its side effects

Tetracycline, specifically oral minocycline or doxycycline are most often used to treat granulomas due to their anti-inflammatory effect

Addressing the Concerns Directly On tumor promotion: The angiogenesis mechanism has generated theoretical concern about potential tumor growth promotion