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[6] NAD+ augmentation may counteract age-related NAD+ loss caused by overactive NAD-consuming enzymes (such as the NADase CD38), thereby supporting mitochondrial maintenance and metabolic homeostasis

The combination of isatuximab-Kd was further investigated in the Phase III IKEMA trial, a randomized, open-label study conducted across 16 countries in North America, South America, Europe, and the AsiaPacific region [54, 64]

doi: 10.1161/01.atv.20.6.1595

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