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Shaking introduces significant mechanical stress that can break the delicate chemical bonds holding the peptide chain in its specific, functional shape

The evidence base spans several decades with consistent findings across gastric ulcer, IBD, and systemic tissue-repair endpoints

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doi: 10.1158/1078-0432.CCR-09-0265 338 Vanpouille-BoxCAlardAAryankalayilMJSarfrazYDiamondJMSchneiderRJet al

The 21-day window is set by TB-500's stability
