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In some embodiments, each L 2 is independently a 6-10 membered heteroaryl

doi: 10.5582/ddt.2013.v7.1.29 494 HattoriHOkudaKMuraseTShigetsuraYNariseKSemenzaGLet al

These findings further extend the utility of GSTO1 inhibitors as anti-inflammatory agents

Hence, DCA participates in decreasing the formation of (1) isoleucine catabolic intermediates, which are neurotoxic, thereby decreasing the incidence of chronic neurological impairment and (2) acetyl-CoA is the precursor of ketogenesis, thereby decreasing ketoacidosis
