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Though the group reported appreciable 1000:1 selectivity for hMC4R affinity compared to hMC1R affinity, functional cAMP assay results were only reported for hMC4R (EC 50 = 88 nM, E max = 85%), seen in Table 1 ( 50 = 31 nM, E max = 105%) but only had partial agonist activity at hMC3R (EC 50 = 39 nM, E max = 31%) ( Conde-Frieboes et al

This fact highlights also the importance of clinical and analytical comparison studies among different SJW preparations to provide information on hyperforin content of considerably safer products

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The expression plasmid was transformed into E