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Other authors propose that the development of ALI and alveolar damage can also occur in other types of respiratory infections, such as the influenza virus H1N1 and the respiratory syncytial virus (RSV), which also put the elderly population at greater risks [34], [35], [36] Oxidative stress in COVID-19 Oxidative stress has been implicated in the manifestation of critical illnesses, including ischemia and reperfusion injury and systemic inflammatory states

The clinician can ask the patient to point to the area of maximal tenderness, which often indicates the highest-yield area for sonographic evaluation

Trained immunity: an overview and the impact on COVID-19

Figure 6 Discussion Epigenetic changes in host cells during COVID-19 have already been described and are associated with the regulation of the SARS-CoV-2 cycle ( ex vivo model, it was demonstrated that vitamin B12 favorably modulates, by methyl-dependent epigenetic mechanisms, the expression of inflammatory genes and the activity of metabolic and signaling pathways related to the hyperinflammation associated with COVID-19 forms that require hospitalization

As these findings continue to develop, ergothioneine supplements are gaining popularity