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This is where the protocol becomes a critical, non-negotiable element of your work

Calycosin has been demonstrated to inhibit tyrosinase activity with an IC50 value of 38.4 M

However, exposure to Hg 2+ conjugated with Pb produces more severe nephropathy, and the proximal tubules appear to be the most sensitive, while other segments are only affected at high doses [29]

6 Future perspectives Metabolomics is to become an important tool in research related to the investigation of drug-induced hepatotoxicity, allowing researchers to assess the deleterious effects of xenobiotics by identifying changes in metabolite levels that uncover the toxic mechanisms at play, the identification of biomarkers of interest suitable for clinical diagnosis and facilitating the development of predictive models

Aldonyte, R., Eriksson, S., Piitulainen, E., Wallmark, A