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Chen DL, Wang ZQ, Zeng ZL, Wu WJ, Zhang DS, Luo HY, et al

This D-retro-inverso configuration preserves the three-dimensional side-chain topology of the original FOXO4 sequence maintaining functional mimicry of the FOXO4 forkhead domains interaction surface with p53 while conferring exceptional proteolytic stability compared to the native L-amino acid sequence

Symptom attribution: hot flashes and genitourinary syndrome are menopause

The detailed section is provided as follows

The RD adopts the evolutionarily conserved Bateman module, consisting of two tandem CBS motifs (CBS-1 and CBS-2) and a surface-exposed loop (residues 516525) extending from a CBS-2 motif (Supplementary Fig