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Tomassini S, et al

Metabolism Cardiovasc Dis

This pattern of Delta sleep inducing peptide is particularly influential during slow-wave sleep (SWS) and rapid eye movement (REM) sleep, the phases when we dream and rejuvenate our minds (Kastin & Akerstrom, 2003)

In intestinal Caco-2 cells, IL-1 decreases TER and increases inulin flux, which is in part mediated by the decreased expression and redistribution of occludin and increased expression of MLCK and MLC phosphorylation.46 It was also shown that the knockdown of nuclear factor-B p65 inhibits the decrease in occludin and increases in MLCK expression, indicating nuclear factor-B-dependent transcriptional regulation by IL-1.47 4

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