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Studies have revealed that upon reaching the BBB, nanoparticles can cross via several mechanisms, including carrier-mediated, receptor-mediated, and adsorptive-mediated transcytosis, as well as passive diffusion, clathrin-mediated endocytosis, and micropinocytosis 59

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Curcumin Gota VS, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG: Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers

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