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An intradermal test dose is recommended before administration in patients suspected of being sensitive to the drug
The authors concluded that due to the high prevalence of MTHFR variants and how crucial it is to assure pregnant women get adequate supplementation, L-methylfolate may be the best option to avoid blood folate deficiencies. The study also notes that excessive ingestion of folic acid could mask an undiagnosed B12 deficiency, and that it was unlikely that methylfolate would mask a B12 deficiency in the same way
In: StatPearls [Internet] 2020
When neurological symptoms like numbness or tingling are already present, that speed matters
This approach may result in less dramatic weight loss or glycemic improvement but can significantly improve tolerability and treatment adherence
