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doi: 10.1007/s00204-009-0455-6

Polyphenols can inhibit AP-1 activity by (i) blocking the binding of AP-1 to DNA, (ii) inactivating the AP-1 proteins, and (iii) interfering with the signal transduction pathways that activate AP-1 [207]

2) and (2) the seven reported suppressor mutations from the yeast model of disease can be all mapped onto the hydrophobic face of the regulatory domain that forms the BatemanBateman interface (Fig

Rheumatoid arthritis is a chronic, systemic, inflammatory disease primarily targeting synovial joints