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NAD + and precursors supplementation NAD + can be directly supplemented intravenously to increase cellular NAD + levels, which has been observed in healthy and elderly cohorts, suggesting improvements in cognitive function and increased expression of antioxidant genes, although these trials were conducted in small cohorts 66,116,117

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These studies suggest that strategies combining NAD + boosting with inhibitors of NAD + -consuming enzymes could be a promising approach to mitigate axon degeneration