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4- Muscle Regeneration and Anti-Atrophy Protection Preclinical work 6 shows IGF-1 regulates matrix metalloproteinases (MMPs) and cytokines during tissue remodeling, ensuring balanced regeneration and reducing fibrotic scarring.IGF-1 also demonstrates protective effects against muscle atrophy by suppressing ubiquitin-proteasome pathways, helping preserve lean mass even during inactivity
According to the 11th edition of the Global Diabetes Map, 589 million adults (aged 2079 years) developed DM in 2024, a figure expected to increase to 853 million by 2050 (3)

2012;2012:e868317

doi: 10.4103/0022-3859.123143
