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In scientific experiments, the combination of vitamins C + E has been shown to eliminate reactive oxygen (superoxide) much more effectively than either vitamin alone, precisely because of this regeneration cycle

As children with SMA may have a limited carnitine synthetic capacity due to significantly diminished skeletal muscle mass, and VPA is known to inhibit carnitine transport and deplete carnitine levels by binding to VPA metabolites, we elected to combine VPA therapy with sufficient supplemental carnitine to avoid concerns about a confounding effect of carnitine depletion

This information is available from in vitro studies with cultured cells, with supportive information from animal and human studies

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