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In contrast, deletion or inhibition of GPX4 causes rapid H 2 O 2 accumulation and RIPK3-mediated necrosome activation 72,73

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Since genetic manipulations (e.g., knockdown, knockout, overexpression, etc.) are not possible in RBCs, pharmacological modulation of surface and intracellular proteins by specific antibodies, inhibitors, and agonists remains the only currently available approach