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A potential strategy for achieving complete and relapse-free tumor remission involves combining conventional chemotherapy to target the bulk of tumor cells with drugs that inhibit glutathione synthesis to eliminate TICs

doi: 10.1016/S0014-5793(00)02396-6

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[PUBMED Abstract] Oliansky DM, Camitta B, Gaynon P, et al.: Role of cytotoxic therapy with hematopoietic stem cell transplantation in the treatment of pediatric acute lymphoblastic leukemia: update of the 2005 evidence-based review