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Solid cancers

This methodical approach to dose finding and titration optimization reflects the maturation of the GLP-1 agonist development paradigm, drawing on lessons learned from the semaglutide and tirzepatide programs

73 People with non-proliferative diabetic retinopathy requiring acute therapy, proliferative diabetic retinopathy and macular edema have not been studied in the SURPASS program and for these patients tirzepatide should be used with caution and appropriate monitoring

Behavioral factorsincluding changes in physical activity, sleep duration, and dietary intakealso co-vary with cycle phase and lipid concentrations, further complicating attribution to ovarian hormones alone [96,136,137]

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