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Description
To address these limitations, half-life extension technologies, such as the addition of albumin-binding domains or Fc engineering, have been developed

This ties into its upregulation of vascular endothelial growth factor (VEGF) receptors, particularly VEGFR2, amplifying signals for new vessel sprouting and tissue regeneration

Zeller, A

Think of the peptide as a key and the receptor as a lock: constant use wears the mechanism, and a planned off period lets it resensitize

Noureddin, M., Mato, J
