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A previous review on OOT for knee OA reinforced this finding, suggesting that while short to medium-term results were encouraging, the included RCTs exhibited discernible methodological constraints [8]

Furthermore, the disease is usually associated with a characteristic phenomenon of honeymoon wear as the clinical response continues while dyskinesia and motor fluctuations wear off after the initial period [14]

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However, this approach faces several challenges, including the potential for the blood-brain barrier (BBB) to mask or dilute CNS-specific signals and the difficulty in distinguishing brain-derived markers from those originating systemically (87,88)