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There can be soreness after an initial treatment, similar to physical therapy, in the same way that one is sore after working out in a gym

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Its important to note that for individuals with adequate vitamin B12 levels, there is limited scientific evidence that B12 injections alone will enhance skin hydration or appearance

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Fortunately, you cannot overdose on vitamin B12, as it is water-soluble, so adding more is not harmful

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doi:10.1016/j.arr.2016.08.006

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Thus, the hematologic and gastrointestinal effects of cobalamin deficiency are reversed by folate supplementation

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