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The current review will focus on four main areas: (1) general description of oxidative stress markers in SLE, (2) alteration of redox state and complication of disease (3) role of redox mechanisms in the initiation and execution phases of apoptosis, and (4) intracellular glutathione and its checkpoints with lymphocyte apoptosis represent novel targets for pharmacological intervention in SLE

For example, fucoxanthin was found to induce a G0/G1 phase block in cancer cells while upregulating GADD45, a DNA repair gene regulated by p53, which helps maintain genomic stability and reduce cancer risk (44)

Intracellular calcium homeostasis and signaling

The results were assessed at 3 months using the dynamics of pain, fatigue, functional impairment (NRS) and the patient-acceptable symptom state (PASS) parameter

Inflammatory mediators such as TNF-alpha and IL-8 levels were also significantly reduced in these patients receiving omega-3 nutritional support, suggesting a reduction in the systemic inflammatory response