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Importantly, the impact of shift intensity, timing, and chronotype remains underexplored 306,308,309

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doi: 10.1038/nrm2067

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Ticagrelor protects against AngII-induced endothelial dysfunction by alleviating endoplasmic reticulum stress

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however, the two drugs were quickly withdrawn from clinical use as a result of inducing lactic acidosis

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