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87 Thus, further exploration of the association between the effects of these drugs on the ALDH1L2 expression and the cellular response to redox stress is needed

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The carriers of CYP3A5 rs776746 A allele were overrepresented in the intentionally overdosed group and were more predisposed to acetaminophen-induced hepatotoxicity than individuals with the G allele, that rendered CYP3A5 enzyme inactive due to aberrant gene splicing [100]
