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10.1039/c1mt00022e 16 Del Prado-AudeloM

& Rinaldi, D

Nrf2deficient mice are generally more susceptible to redox disturbances and easily developing drug toxicity.48, 49 For instance, loss of Nrf2 initiates a detrimental cascade of reduced GST expression and elevates ROS level, ultimately leading to DNA damage and tumorigenesis.50 NFE2L2 gene knockout mice are more sensitive to exogenous chemicals, leading to the formation of bleomycininduced pulmonary fibrosis and hyperoxic lung injury51 as well as acetylhydrolaseinduced liver cancer.52 Oxidative tissue damage after ischemia and reperfusion, including that resulting in noiseinduced hearing loss, is effectively suppressed by Nrf2 activation through its antioxidant function.53 2.6

The substances affected include BPC-157, LL-37, DiHexa, DSIP, Epitalon, injectable GHK-Cu, KPV, PEG-MGF, Melanotan II, MOTs-C, Semax, and TB-500

A glutathione product may include other tone-support ingredients, while an EGT product may be more focused on antioxidant resilience