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In a recent review (2018) by the famous Cochrane Institute, it was reported that studies which had been published on this topic only provided very low-quality evidence that oral B12 is as efficacious as intramuscular B12

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Conversely, there is growing evidence that chronic and/or exaggerated alterations in the redox balance play an important role in many acute and chronic diseases, such as cancer, cardiovascular disease, diabetes, sepsis, and general infections

This consistency proves essential for brands developing products that will undergo clinical testing or make specific efficacy claims, as batch-to-batch variation can compromise study results or product performance