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R169Q, R169P and R169W are all variants associated with SPCD 11 , all of which we hypothesise affect the positioning of both D165 and E220, and subsequently the gating interaction between R459 and E220

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Use a clean measuring device for each dose and keep the bulk bottle sealed and refrigerated if recommended

However, the potential risks, particularly in vulnerable populations, highlight the need for careful management and clinical oversight

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