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This deficit is the one of the main reason that those with chronic illness suffer from recurrent bacterial, viral, parasitic, and fungal infections, cancers, and toxic metal sensitivities

There are speculations that non-pathogenic commensal microorganisms, which co-evolved with humans, have been a source of immunomodulatory signals for the human body (the old friends hypothesis), and now prevent the development of immune-mediated chronic diseases (the hygiene hypothesis), with the proper composition of the microbiome promoting the maintenance of the bodys immune balance (the biodiversity hypothesis) [1, 39, 53, 54]

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doi: 10.1038/s41586-018-0177-0 74 KratchmarovRViragovaSKimMJRothmanNJLiuKReizisBet al

The study was done on males who had been abused as children.[ref] An interaction between COMT and MAOB has also been seen in research on the susceptibility to OCD (obsessive-compulsive disorder).[ref] This possible link seems to be specific to MAO B and not MAO-A