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Este efecto se ha medido mediante protocolos de muestreo seriado de GH

S4A), and THP1 macrophages (Fig

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Similarly, in breast cancer (MCF-7 and MDA-MB-231) cells, aloe-emodin selectively inhibits proliferation and promotes apoptosis by modulating Bcl-2 protein levels through miR-15a / miR-161 upregulation [501], competitively inhibiting telomerase and stabilizing G-quadruplex structure, suppressing hTERT transcription in breast cancer (MDA-MB-453, MDA-MB-231, and MCF-7) cells through E2F1 upregulation and c-Myc downregulation, as well as promoter demethylation [502]

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