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[PubMed: 2422981] 21

The 2 individual patient-reported components (stool frequency and rectal bleeding) are part of the Mayo score and were not powered for statistical significance VISIBLE 1 TRIAL EXPLORATORY END POINTS: PATIENT-REPORTED OUTCOMES Partial Mayo Score and symptom subscores by study visit 15 * The ENTYVIO IV arm is a reference arm and not powered for statistical significance

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Previous studies have shown that cytosolic proteins can regulate VDAC function and affect mitochondrial outer membrane permeability ( Since ALPS motifs bind to membranes in a specific manner recognizing lipid packaging defects, it is interesting to consider ALPS phosphorylation as a functional regulatory mechanism for ArfGAP1 localization