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Findings such as these may suggest a neuroprotective role for siponimod in the CNS, by countering MIMS and AIMS development, and justify its feasibility as a therapeutic option in SPMS (163)
Moreover, diabetes complications are not limited to DN alone, and there may be connections between various complications


Autistic symptom changes were not evaluated as part of the study, but children in both groups showed improvement in cysteine, plasma sulfate, and whole-blood glutathione levels